Bimectin

Dosage Form: FOR ANIMAL USE ONLY
Bimeda, Inc. Division of Cross Vetpharm Group (ivermectin) Bimectin Pour-On for Cattle ANADA 200-318, Approved by FDA Contains 5 mg ivermectin/mL Parasiticide Consult you veterinarian for assistance in the diagnosis, treatment and control of parasitism. Introduction: Bimectin (ivermectin) Pour-On delivers internal and external control in one convenient low-volume application. Bimectin Pour-On contains ivermectin, a unique chemical entity. ANADA 200-318, Approved by FDA

Indications

Bimectin (ivermectin) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites.

Gastrointestinal Roundworms

Ostertagia ostertagi             (adults and L4)

       (indcluding inhibited state)

Haemonchus placei             (adults and L4)

Trichostrongylus axei          (adults and L4)

Cooperia oncophora            (adults and L4)

Cooperia punctata              (adults and L4)

Cooperia surnabada            (adults and L4)

Strongyloides papillosus      (adults)

Oesophagostomum radiatum     (adults and L4)

Lungworms

Dictyocaulus viviparus           (adults and L4)

Cattle Grubs

Hypoderma bovis

Mites

Sarcoptes scabei var. bovis

Lice

Lingonathus vituli

Haematopinus eurysternus

Damalia bovis

Solenopotes capillatus

Horn Flies

Haematobia irritans

Treatment of Cattle for Horn Flies:  Bimectin (ivermectin) Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing.  For best results Bimectin (ivermectin) Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites.  Consult your veterinarian or an entomologist for the must effective timing of applications.


Persistent Activity:  Bimectin (ivermectin) Pour-On has been proved to effectively control infections and to protect cattle from re-infection with Ostertagia Ostertagi, Oesophagostomum radiatum, Haemonchus placei, Trichostrongyles axei,  Cooperia punctata and Cooperia oncophora for 14 days after treatment.

Dosage

Dosage:  The dose rate is 1 mL for each 22lb of body weight.  The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.

Administration:  Squeeze-Measure-Pour System (1 Liter Bottle with 25 mL Measuring Cap)

Attach metering cap to the bottle.

Select the correct dose rate by rotating the adjuster cap in either direction to position the dose indicator to the appropriate dose.

Gently squeeze the bottle to fill to level (any excess will return to the bottle) and then tip and apply to animal along the topline.

BackPack (84.5 fl oz/2.5 Liter Pack and 169 fl. oz/5 Liter Pack.

Connect the applicator gun to the backpack as follows:  Attach the open end of the draw-off tubing to the dosing equipment.  (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended.  Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage).

Replace the shipping cap with the draw-off cap and tighten down.

Attach draw-off tubing to the draw-off cap.

Gently prime the applicator gun, checking for leaks.

Follow the manufacturer's directions for adjusting the dose.

When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container.  To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.

Free standing 338 fl. oz./10 Liter bottle and 676 fl. oz./20 Liter bottle

Connect the applicator gun to the 338 fl. oz./10 L and 676 fl. oz./20 L bottle as follows: Attach the open end of the draw-off tubing to the dosing equipment.  (Because of the solvents used in the formulation, only the Protector Drench Gun from Instrument Supply Limited, or equivalent is recommended.  Other applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage.)

Replace the shipping cap with the draw-off cap.

Gently prime the applicator gun, checking for leaks.

Follow the manufacturer's directions for adjusting the dose.

When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container.  To prevent removal of special lubricants from the Protector Drench Gun, the gun and tubing must not be washed.

Mode of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action.  Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.  This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.  Compounds of this class may also interact with other ligand-gated chloride channel, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).  The margin of safety of compounds of this class is attributable to the fact that mammals do not have the glutamate-gated chloride channel, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channel and they do not readily cross the blood-brain barrier.

Animal Safety

Studies conducted in the U.S.A. have demonstrated the safety margin of ivermectin.  Based on the plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

Residue Information

Cattle must not be treated within 48 days of slaughter for human consumption.  Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age.  A withdrawal period has not been established for this product in pre-ruminating calves.   Do not use in calves to be processed for veal.

Warning

WARNING!  NOT FOR USE IN HUMANS.

The product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin.  To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves.  If accidental skin contact occurs, wash immediately with soap and water.  If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

Keep this and all drugs out of the reach of children.

The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information.  To report advers effects, obtain an MSDS or for assistance contact Bimeda, Inc. at 1-888-524-6332.

WARNING!  FLAMMABLE!

KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.

Precautions

Store away from excessive heat (104 degress F/40 degrees C) and protect from light.


Use only in well-ventilated areas or outdoors.


Close container tightly when not in use.


Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced.


Do not use when rain is expected to wet cattle within six hours after treatment.


This product is for application to skin surface only.  Do not give orally or parenterally.


Cloudiness in the formulation may occur when Bimectin (ivermectin) Pour-On is stored at temperatures below 32 degrees F.  Allowing to warm at room temperature will restore the normal appearance without affecting efficacy.


Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g., caked mud or manure.


Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, Bimectin (ivermectin) Pour-On is not recommended for use in species other than cattle.


When to Treat Cattle with Grubs:  Bimectin (ivermectin) Pour-On effectively controls all stages of cattle grubs.  However, proper timing of treatment is important.  For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season.  While this is not peculiar to ivermectin, desctruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas my cause undesirable host-parasite reactions.  Killing Hypoderma lineatum when it is in the esophageal tissues may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis.  Cattle should be treated either before or after these stages of grub development.


Cattle treated with Bimectin (ivermectin) Pour-On at the end of the fly season may be re-treated with ivermectin during the winter without danger of grub-related reactions.  For further information and advice on a planned parasite control program, consult your veterinarian.

Environmental Safety

Studies indicate that when ivermectin comes in contact with soil, it readily and tightly binds too the soil and becomes inactive over time.  Free ivermectin may adversely affect fish or certain aquatic  organisms.  Do not permit cattle to enter lakes, streams, or ponds for at least 6 hours after treatment.  Do not contaminate water by direct application or by the improper disposal of drug containers.  Dispose of containers in an approved landfill or by incineration.

As with other avermectins, ivermectin is excreted in the dung or treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction.  The magnitude and duration of such effects are species and life-cycle specific.  When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependant insects.

Package Information

Bimectin (ivermectin) Pour-On is available in a 33.8 fl oz/1 liter bottle with a measure-pour system, an 84.5 fl. oz/2.5 Liter, a 169 fl. oz/5 Liter, a 338 fl. oz/10 Liter bottle and a 676 fl. oz./20 Liter bottle intended for use with appropriate automatic dosing equipment.

Package Label Display Panel

Bimectin

(ivermectin)

Pour-On for Cattle

Contains 5 mg ivermectin/mL

Parasiticide

Kills:  Roundworms (including Brown Stomach Worm), Lungworms, Grubs, Sucking Lice, Biting Lice, Mange Mites, Horn Flies

Net Contents:  169 fl oz (5 Liter)

WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME AND OTHER SOURCES OF IGNITION.

WARNING! NOT FOR USE IN HUMANS.

ANADA 200-318, Approved by FDA

Bimeda

Bimectin POUR-ON  ivermectin  solution

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 61133-6014 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Ivermectin (Ivermectin) Ivermectin 5 mg  in 20 L

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 61133-6014-2 20 L In 1 CONTAINER None 2 61133-6014-3 5 L In 1 CARTON None 3 61133-6014-1 5 L In 1 CONTAINER None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANADA	ANADA200318	10/01/2009

Labeler - Bimeda, Inc. Division of Cross Vetpharm Group (043653216)

Revised: 12/2009Bimeda, Inc. Division of Cross Vetpharm Group

BiferaRx

Pronunciation: SYE-an-oh-koe-BAL-a-min/FOE-lik AS-id/EYE-urn
Generic Name: Cyanocobalamin/Folic Acid/Iron
Brand Name: Examples include BiferaRx and Ferrex 150 Forte

Accidental overdose of products that contain iron is a leading cause of fatal poisoning in children younger than 6 years old. Keep this and all medicines out of the reach of children. In case of accidental ingestion, call the poison control center or a doctor at once.

BiferaRx is used for:

Preventing and treating certain types of anemia (eg, caused by low blood iron levels, poor nutrition). It may also be used for other conditions as determined by your doctor.

BiferaRx is a vitamin, folic acid, and iron combination. It works by providing vitamins, folic acid, and iron to the body.

Do NOT use BiferaRx if:

• you are allergic to any ingredient in BiferaRx


• you have certain iron metabolism problems (eg, hemosiderosis, hemochromatosis) or you have high levels of iron in your blood

Contact your doctor or health care provider right away if any of these apply to you.

Before using BiferaRx:

Some medical conditions may interact with BiferaRx. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have bowel problems (eg, colitis, Chron disease, diverticulitis), certain blood disorders (eg, hemolytic or pernicious anemia, porphyria cutanea tarda, thalassemia), or a peptic ulcer


• if you have had multiple blood transfusions

Some MEDICINES MAY INTERACT with BiferaRx. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Fluorouracil because the risk of its side effects may be increased by BiferaRx


• Bisphosphonates (eg, alendronate), cephalosporins (eg, cefdinir), hydantoins (eg, phenytoin), levodopa, methyldopa, mycophenolate, penicillamine, quinolones (eg, ciprofloxacin, levofloxacin), tetracyclines (eg, doxycycline), or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by BiferaRx

This may not be a complete list of all interactions that may occur. Ask your health care provider if BiferaRx may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use BiferaRx:

Use BiferaRx as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take BiferaRx by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Do not take an antacid within 1 hour before or 2 hours after you take BiferaRx.


• Avoid taking BiferaRx with dairy products; they may interfere with the absorption of the iron in BiferaRx.


• If you also take a bisphosphonate (eg, alendronate), a cephalosporin (eg, cefdinir), eltrombopag, levodopa, methyldopa, penicillamine, a quinolone (eg, ciprofloxacin), or a tetracycline (eg, doxycycline), ask your doctor or pharmacist how to take it with BiferaRx.


• If you miss a dose of BiferaRx, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use BiferaRx.

Important safety information:

• Do NOT take more than the recommended dose without checking with your doctor.


• Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use BiferaRx unless your doctor tells you to.


• BiferaRx has folic acid and iron in it. Before you start any new medicine, check the label to see if it also has folic acid or iron in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• BiferaRx may discolor the stools. This is normal and not a cause for concern.


• BiferaRx has iron in it. Iron overdose is a leading cause of fatal poisoning in children younger than 6 years of age. In case of an overdose, call a doctor or poison control center right away.


• BiferaRx may interfere with certain lab tests, including tests used to check for blood in the stool. Be sure your doctor and lab personnel know you are taking BiferaRx.


• Lab tests, including hematocrit, hemoglobin levels, and blood iron levels, may be performed while you use BiferaRx. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• BiferaRx should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using BiferaRx while you are pregnant. BiferaRx is found in breast milk. If you are or will be breast-feeding while you use BiferaRx, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of BiferaRx:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dark or green stools; diarrhea; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; severe or persistent nausea, vomiting, or stomach pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: BiferaRx side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include black, tarry, or bloody stools; blue or unusually pale skin; drowsiness or dizziness; fast heartbeat; increased thirst or urination; seizures; severe or persistent nausea, vomiting, diarrhea, or stomach pain; sluggishness; vomiting blood; weakness.

Proper storage of BiferaRx:

Store BiferaRx at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep BiferaRx out of the reach of children and away from pets.

General information:

• If you have any questions about BiferaRx, please talk with your doctor, pharmacist, or other health care provider.


• BiferaRx is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about BiferaRx. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More BiferaRx resources

• BiferaRx Side Effects (in more detail)
• BiferaRx Use in Pregnancy & Breastfeeding
• BiferaRx Drug Interactions
• BiferaRx Support Group
• 0 Reviews for BiferaRx - Add your own review/rating

• multivitamin with iron Concise Consumer Information (Cerner Multum)


• Allbee-C 800 with Iron Concise Consumer Information (Cerner Multum)


• Ferotrin Prescribing Information (FDA)


• Ferralet 90 Prescribing Information (FDA)


• Ferrex 150 Forte Prescribing Information (FDA)


• Ferrex 150 Forte Plus Prescribing Information (FDA)


• Ferrex 28 Prescribing Information (FDA)


• FerroGels Forte Prescribing Information (FDA)


• Hematogen Forte Prescribing Information (FDA)


• Integra F Prescribing Information (FDA)


• Integra Plus Prescribing Information (FDA)


• Irospan 24/6 Prescribing Information (FDA)


• NovaFerrum Prescribing Information (FDA)


• Tricon Prescribing Information (FDA)

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• Anemia
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biperiden

bye-PER-i-den

Commonly used brand name(s)

In the U.S.

• Akineton

Available Dosage Forms:

• Tablet

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Anticholinergic

Uses For biperiden

Biperiden is used alone or together with other medicines (e.g., levodopa) to treat Parkinson's disease. By improving muscle control and reducing stiffness, biperiden allows more normal movements of the body as the disease symptoms are reduced.

Biperiden is also used to control severe muscle reactions and other side effects from certain medicines that are used to treat severe nausea or nervous, mental, or emotional conditions (e.g., chlorpromazine [Thorazine®], perphenazine [Trilafon®], prochlorperazine [Compazine®], promethazine [Phenergan®], thioridazine [Mellaril®]).

biperiden is available only with your doctor's prescription.

Before Using biperiden

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For biperiden, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to biperiden or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of biperiden in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of biperiden in geriatric patients. However, elderly men are more likely to have age-related prostate problems, which may require caution for patients receiving biperiden.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking biperiden, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using biperiden with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium

Using biperiden with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of biperiden. Make sure you tell your doctor if you have any other medical problems, especially:

• Bowel blockage or


• Glaucoma, narrow-angle or


• Megacolon (colon is enlarged)—Should not be used in patients with these conditions.

• Enlarged prostate or


• Epilepsy (seizures) or


• Glaucoma or


• Heart rhythm problems—Use with caution. May make these conditions worse.

Proper Use of biperiden

Take biperiden every day exactly as ordered by your doctor in order to improve your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take biperiden with food to reduce stomach irritation.

Dosing

The dose of biperiden will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of biperiden. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For side effects caused by other medicines:
    
    • Adults—2 milligrams (mg) one to three times per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For Parkinson's disease:
    
    • Adults—At first, 2 milligrams (mg) three or four times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 16 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of biperiden, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using biperiden

It is important that your doctor check your progress at regular visits to allow changes in your dose and to check for any unwanted effects.

If you develop any unusual or strange thoughts and behavior while receiving biperiden, be sure to discuss it with your doctor. Some changes that have occurred in people receiving biperiden are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, visual hallucinations (seeing things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

Biperiden may cause drowsiness, trouble with controlling movements, or trouble with thinking or seeing clearly. Make sure you know how you react to biperiden before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

biperiden will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking biperiden.

biperiden Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Anxiety


• chest pain or discomfort


• chills


• cold sweats


• confusion


• confusion about identity, place, and time


• decrease in frequency of urination


• decrease in urine volume


• difficulty in passing urine (dribbling)


• disturbed behavior


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position


• dry mouth


• false or unusual sense of well-being


• hyperventilation


• irregular heartbeats


• irregular, twisting uncontrolled movement of the face, hands, arms, or legs


• irritability


• nervousness


• painful urination


• restlessness


• shaking


• shortness of breath


• slow or irregular heartbeat


• trouble sleeping


• unusual tiredness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness


• chest pain or discomfort


• convulsions


• decreased awareness or responsiveness


• decreased secretions of the mouth, pharynx, nose, or bronchi


• delusions of persecution, mistrust, suspiciousness, or combativeness


• dizziness


• dry mouth


• enlarged pupils


• face is warm or hot to touch


• fainting


• fast, slow, pounding, or irregular heartbeat or pulse


• foul-smelling breath


• holding false beliefs that cannot be changed by fact


• lightheadedness


• loss of consciousness


• loss of memory


• no breathing


• redness to face


• seeing, hearing, or feeling things that are not there


• severe sleepiness


• shakiness and unsteady walk


• trouble sitting still


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual excitement, nervousness, or restlessness


• warm, dry skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Blurred vision


• difficulty having a bowel movement (stool)


• drowsiness


• nausea


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: biperiden side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More biperiden resources

• Biperiden Side Effects (in more detail)
• Biperiden Dosage
• Biperiden Use in Pregnancy & Breastfeeding
• Biperiden Drug Interactions
• Biperiden Support Group
• 0 Reviews for Biperiden - Add your own review/rating

• biperiden Concise Consumer Information (Cerner Multum)


• Biperiden MedFacts Consumer Leaflet (Wolters Kluwer)


• Biperiden Professional Patient Advice (Wolters Kluwer)


• Biperiden Hydrochloride Monograph (AHFS DI)

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Biothrax

Generic Name: anthrax vaccine (ANTH rax vax EEN)

Brand Names: Biothrax

What is anthrax vaccine?

Anthrax is a disease caused by infection with a spore-forming bacteria. It usually occurs in animals such as sheep, goats, cattle, deer, antelope, and other herbivores. Anthrax can also occur in people who are exposed to an infected animal or other source of the anthrax bacteria.

Anthrax is spread to a human through the skin, the stomach, or the lungs. The bacteria can enter the skin through a cut or wound that comes into contact with products from an infected animal (such as meat, wool, hide, or hair). Infection can also occur through the lungs when a person inhales the bacterial spore, or through the stomach when a person eats undercooked meat from an infected animal.

Anthrax is most common in agricultural regions lacking in good veterinary prevention programs, especially in Africa, Asia, Central and South America, the Carribean, the Middle East and Southeastern Europe. Although less common, anthrax does occur in the United States each year among both wild game animals and domestic livestock.

Anthrax is a serious disease that can spread quickly throughout the body and it is fatal in a high number of cases, especially when acquired through the lungs.

The anthrax vaccine is used to help prevent this disease in people exposed to the bacteria through the skin or lungs. This vaccine works by exposing you to an antigen protein that causes your body to develop immunity to the disease. Anthrax vaccine does not contain live or killed forms of the bacteria that causes anthrax.

Anthrax vaccine will not treat an active infection that has already developed in the body.

Like any vaccine, the anthrax vaccine may not provide protection from disease in every person.

What is the most important information I should know about anthrax vaccine?

You should not receive this vaccine if you have ever had a life-threatening allergic reaction to an anthrax vaccine, or if you have ever had anthrax disease acquired through the skin.

Before receiving this vaccine, tell the doctor if you have ever had an allergic reaction to a vaccine, or if you have a weak immune system, if you are pregnant or breast-feeding, if you are allergic to latex rubber, if you are receiving chemotherapy or radiation, or if you have a history of Guillain-Barré syndrome.

You can still receive a vaccine if you have a cold or mild fever. In the case of a more severe illness with a high fever or any type of infection, wait until you get better before receiving this vaccine.

Before receiving anthrax vaccine, tell the doctor about all other vaccines you have recently received. Also tell the doctor if you have recently received drugs or treatments that can weaken the immune system, such as steroids, psoriasis or arthritis medications, medicines to treat or prevent organ transplant rejection, or chemotherapy or radiation treatments. You may not be able to receive the anthrax vaccine, or may need to wait until the other treatments are finished.

Becoming infected with anthrax is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Anthrax vaccine will not treat an active infection that has already developed in the body.

What should I discuss with my health care provider before receiving anthrax vaccine?

You should not receive this vaccine if you have ever had a life-threatening allergic reaction to an anthrax vaccine, or if you have ever had anthrax disease acquired through the skin.

Before receiving this vaccine, tell the doctor if you have ever had an allergic reaction to any type of vaccine, or if you have:

• 
  

  an allergy to latex rubber;

  
  


• 
  

  a weak immune system caused by disease (such as cancer, HIV, or AIDS), or by taking certain medicines;

  
  


• 
  

  a history of infection with anthrax;

  
  


• 
  

  a history of Guillain-Barré syndrome;

  
  


• 
  

  if you are pregnant or breast-feeding; or

  
  


• 
  

  if you have received cancer chemotherapy, radiation treatment, or steroid medications in the past 3 months.

  
  

You can still receive a vaccine if you have a cold or mild fever. In the case of a more severe illness with a high fever or any type of infection, wait until you get better before receiving this vaccine.

Vaccines generally should not be given to a pregnant woman. However, not vaccinating the mother could be more harmful to the baby if the mother becomes infected with a disease that this vaccine could prevent. Your doctor will decide whether you should receive this vaccine, especially if you have a high risk of infection with anthrax.

How is anthrax vaccine given?

This vaccine is given as an injection (shot) under the skin. You will receive this injection in a doctor's office or other clinic setting.

Anthrax vaccine is recommended for adults in the following situations:

• 
  

  people who handle anthrax bacteria in a laboratory or other work setting;

  
  


• 
  

  people who handle animal hides or furs imported from areas where anthrax is common;

  
  


• 
  

  people who handle meat or other animal products in areas where anthrax is common;

  
  


• 
  

  veterinarians who travel to countries where anthrax is common; and

  
  


• 
  

  military personnel at risk of exposure through potential biological warfare when anthrax may be used as a weapon.

  
  

The anthrax vaccine is given in a series of 6 shots. The first 3 shots are given 2 weeks apart. The following three 3 shots are given 6, 12, and 18 months after the first shot. An annual booster shot is then recommended every year during possible exposure to anthrax. Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by the health department of the state where you live.

You may receive anthrax vaccine at the same time as other vaccines.

What happens if I miss a dose?

Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.

Be sure you receive all recommended doses of this vaccine. If you do not receive the full series of vaccines, you may not be fully protected against the disease.

What happens if I overdose?

An overdose of this vaccine is unlikely to occur.

What should I avoid before or after receiving anthrax vaccine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity after you receive this vaccine.

Anthrax vaccine side effects

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot. Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with anthrax is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect (some are rare but serious) such as:

• 
  

  severe swelling or a hard lump where the shot was given;

  
  


• 
  

  severe swelling spreading to other parts of your arm;

  
  


• 
  

  fever, chills, body aches, nausea, flu symptoms;

  
  


• 
  

  pale skin, easy bruising or bleeding;

  
  


• 
  

  confusion, changes in mood or behavior;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  blistering, redness, and swelling or warmth of the skin;

  
  


• 
  

  weakness, numbness or tingly feeling in your feet spreading upward;

  
  


• 
  

  problems with vision, hearing, speech, swallowing, or bladder and bowel functions;

  
  


• 
  

  severe lower back pain; or

  
  


• 
  

  slow heart rate, trouble breathing, weak pulse, or feeling like you might pass out.

  
  

Less serious side effects include:

• 
  

  mild redness, warmth, itching, or tenderness where the shot was given;

  
  


• 
  

  low fever;

  
  


• 
  

  feeling tired or weak;

  
  


• 
  

  headache, dizziness;

  
  


• 
  

  mild pain or stiffness in the injected arm;

  
  


• 
  

  joint or muscle pain;

  
  


• 
  

  swelling in your hands or feet; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect anthrax vaccine?

Before receiving this vaccine, tell the doctor about all other vaccines you have recently received.

Also tell the doctor if you have recently received drugs or treatments that can weaken the immune system, including:

• 
  

  an oral, nasal, inhaled, or injectable steroid medicine;

  
  


• 
  

  medications to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders, such as azathioprine (Imuran), efalizumab (Raptiva), etanercept (Enbrel), leflunomide (Arava), and others; or

  
  


• 
  

  medicines to treat or prevent organ transplant rejection, such as basiliximab (Simulect), cyclosporine (Sandimmune, Neoral, Gengraf), muromonab-CD3 (Orthoclone), mycophenolate mofetil (CellCept), sirolimus (Rapamune), or tacrolimus (Prograf).

  
  

If you are using any of these medications, you may not be able to receive the vaccine, or may need to wait until the other treatments are finished.

There may be other drugs that can affect the anthrax vaccine. Tell your doctor about all the prescription and over-the-counter medications you have received. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. While you are receiving the anthrax vaccine series, do not start using a new medication without telling your doctor.

More Biothrax resources

• Biothrax Side Effects (in more detail)
• Biothrax Use in Pregnancy & Breastfeeding
• Biothrax Drug Interactions
• Biothrax Support Group
• 0 Reviews for Biothrax - Add your own review/rating

• Biothrax Advanced Consumer (Micromedex) - Includes Dosage Information


• BioThrax Consumer Overview

Compare Biothrax with other medications

• Anthrax Prophylaxis

Where can I get more information?

• Your doctor or pharmacist may have information about this vaccine written for health professionals that you may read. You may also find additional information from your local health department or the Centers for Disease Control and Prevention.

See also: Biothrax side effects (in more detail)

BiDil

Pronunciation: eye-soe-SOR-bide die-NYE-trate/hye-DRAL-a-zeen
Generic Name: Isosorbide Dinitrate/Hydralazine
Brand Name: BiDil

BiDil is used for:

Treating heart failure in certain patients. It may also be used for other conditions as determined by your doctor.

BiDil is a vasodilator combination. It works by relaxing and dilating (opening) the blood vessels in the body, allowing blood to flow through the vessels easier and at a lower pressure.

Do NOT use BiDil if:

• you are allergic to nitrates or to any ingredient in BiDil


• you are taking certain medicines for erectile or lung problems (eg, phosphodiesterase inhibitors [sildenafil, vardenafil, tadalafil])

Contact your doctor or health care provider right away if any of these apply to you.

Before using BiDil:

Some medical conditions may interact with BiDil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have blood problems (eg, anemia), dehydration problems, heart problems, low blood pressure, liver problems, lupus, or an overactive thyroid, or you have had a recent head injury or recent heart attack

Some MEDICINES MAY INTERACT with BiDil. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that affect your blood vessels, medicines that treat high blood pressure, or other vasodilators because they may increase the risk of BiDil's side effects


• Monoamine oxidase (MAO) inhibitors (eg, furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) or phosphodiesterase inhibitors (sildenafil, tadalafil, vardenafil) because the risk of severe low blood pressure may be increased or because serious side effects may occur


• Beta-blockers (eg propranolol) or lisinopril because the risk of their side effects may be increased by BiDil

This may not be a complete list of all interactions that may occur. Ask your health care provider if BiDil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use BiDil:

Use BiDil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take BiDil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Drinking extra fluids while you are taking BiDil is recommended. Check with your doctor for instructions.


• Take BiDil on a regular schedule to get the most benefit from it. Taking BiDil at the same time each day will help you remember to take it.


• Continue to take BiDil even if you feel well. Do not miss any doses.


• If you miss a dose of BiDil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use BiDil.

Important safety information:

• BiDil may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use BiDil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using BiDil; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• BiDil may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, fever, low fluid intake, excessive sweating, vomiting, or diarrhea can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of dizziness, lightheadedness, or weakness. If fainting occurs, notify your doctor as soon as possible.


• BiDil may cause a vitamin B₆ deficiency. Talk with your doctor for more information.


• Tell your doctor or dentist that you take BiDil before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including blood pressure checks, may be performed while you use BiDil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use BiDil with caution in the ELDERLY; they may be more sensitive to its effects.


• BiDil should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using BiDil while you are pregnant. It is not known if BiDil is found in breast milk. If you are or will be breast-feeding while you use BiDil, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of BiDil:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; lightheadedness; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine produced; chest pain; difficult urination; fainting; fast or irregular heartbeat; fever, chills, or sore throat; joint pain; numbness or tingling of the skin; persistent fatigue or weakness; runny nose; severe or persistent headache or dizziness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: BiDil side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; confusion; fast or irregular heartbeat; flushing; severe headache; shock.

Proper storage of BiDil:

Store BiDil at 77 degrees F (25 degrees C) in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep BiDil out of the reach of children and away from pets.

General information:

• If you have any questions about BiDil, please talk with your doctor, pharmacist, or other health care provider.


• BiDil is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about BiDil. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More BiDil resources

• BiDil Side Effects (in more detail)
• BiDil Use in Pregnancy & Breastfeeding
• BiDil Drug Interactions
• BiDil Support Group
• 0 Reviews for BiDil - Add your own review/rating

• BiDil Prescribing Information (FDA)


• BiDil Consumer Overview

Compare BiDil with other medications

• Heart Failure

Bisa-Lax Suppositories

Pronunciation: bis-AK-oh-dil
Generic Name: Bisacodyl
Brand Name: Examples include Bisa-Lax and Dulcolax

Bisa-Lax Suppositories are used for:

Relieving occasional constipation and irregularity. It may also be used for other conditions as determined by your doctor.

Bisa-Lax Suppositories are a stimulant laxative. It acts directly on the bowels, stimulating the bowel muscles to cause a bowel movement.

Do NOT use Bisa-Lax Suppositories if:

• you are allergic to any ingredient in Bisa-Lax Suppositories


• you have severe stomach pain; appendicitis; severe constipation; stomach, intestinal, or rectal bleeding; or intestinal blockage


• you are having abdominal surgery

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bisa-Lax Suppositories:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart failure, abnormal levels of fluids or electrolytes in your body, nausea, vomiting, or undiagnosed stomach pain

Some MEDICINES MAY INTERACT with Bisa-Lax Suppositories. However, no specific interactions with Bisa-Lax Suppositories are known at this time.

Ask your health care provider if Bisa-Lax Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bisa-Lax Suppositories:

Use Bisa-Lax Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Remove the wrapper from the suppository.


• Insert suppository well up into the rectum as directed by your doctor or on the package labeling. Retain the suppository for 15 to 20 minutes.


• If you have hemorrhoids, coat the tip of the suppository with petroleum jelly before inserting.


• Drinking extra fluids while you are using Bisa-Lax Suppositories are recommended. Check with your doctor for instructions.


• If you miss a dose of Bisa-Lax Suppositories and are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Bisa-Lax Suppositories.

Important safety information:

• Do not use for longer than 1 week without checking with your doctor. Using Bisa-Lax Suppositories for a long time may result in loss of normal bowel function.


• Do not take additional laxatives or stool softeners with Bisa-Lax Suppositories unless directed by your doctor.


• Rectal bleeding or failure to have a bowel movement after use of a laxative may be a sign of a serious condition. Stop use and contact your doctor.


• If you develop nausea, vomiting, or stomach pain, stop using Bisa-Lax Suppositories and check with your doctor.


• If you notice a sudden change in bowel habits that lasts for 2 weeks or more, do not continue using Bisa-Lax Suppositories. Instead, check with your doctor.


• Use Bisa-Lax Suppositories with caution in the ELDERLY; they may be more sensitive to its effects.


• Bisa-Lax Suppositories are not recommended for use in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bisa-Lax Suppositories while pregnant. It is not known if Bisa-Lax Suppositories are found in breast milk. If you are or will be breast-feeding take Bisa-Lax Suppositories, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Bisa-Lax Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cramps; faintness; stomach discomfort.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Bisa-Lax side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include diarrhea; stomach cramps.

Proper storage of Bisa-Lax Suppositories:

Store Bisa-Lax Suppositories at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container away from heat, moisture, and light. Do not store in the bathroom. Keep Bisa-Lax Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Bisa-Lax Suppositories, please talk with your doctor, pharmacist, or other health care provider.


• Bisa-Lax Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bisa-Lax Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bisa-Lax resources

• Bisa-Lax Side Effects (in more detail)
• Bisa-Lax Use in Pregnancy & Breastfeeding
• Bisa-Lax Drug Interactions
• Bisa-Lax Support Group
• 0 Reviews for Bisa-Lax - Add your own review/rating

Compare Bisa-Lax with other medications

• Bowel Preparation
• Constipation

Biospec DMX Elixir

Pronunciation: DEX-troe-meth-OR-fan/gwye-FEN-e-sin
Generic Name: Dextromethorphan/Guaifenesin
Brand Name: Examples include Biospec DMX and Robitussin DM

Biospec DMX Elixir is used for:

Temporarily relieving cough due to the common cold, upper respiratory tract infections, sinus inflammation, sore throat, or bronchitis.

Biospec DMX Elixir is a combination of an expectorant (guaifenesin) and a cough suppressant (dextromethorphan). It works by loosening mucus and lung secretions in the chest and making coughs more productive.

Do NOT use Biospec DMX Elixir if:

• you are allergic to any ingredient in Biospec DMX Elixir


• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, selegiline) within the last 14 days


• you are taking a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Biospec DMX Elixir:

Some medical conditions may interact with Biospec DMX Elixir. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have chronic cough, chronic bronchitis, or any breathing problems, such as asthma, emphysema, or chronic obstructive pulmonary disease (COPD)

Some MEDICINES MAY INTERACT with Biospec DMX Elixir. Tell your health care provider if you are taking any other medicines, especially any of the following:

• MAOIs (eg, selegiline) and SSRIs (eg, fluoxetine) because the risk of toxic side effects may be increased by Biospec DMX Elixir

This may not be a complete list of all interactions that may occur. Ask your health care provider if Biospec DMX Elixir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Biospec DMX Elixir:

Use Biospec DMX Elixir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Biospec DMX Elixir by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure this dose.


• To help Biospec DMX Elixir work, drink plenty of extra fluids while taking Biospec DMX Elixir, unless your health care provider instructed otherwise.


• If you miss a dose of Biospec DMX Elixir and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Biospec DMX Elixir.

Important safety information:

• Biospec DMX Elixir may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Biospec DMX Elixir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If your cough lasts for more than 1 week or comes back, or if you also have a fever, rash, or persistent headache, contact your health care provider. A persistent cough could be a sign of a serious condition.


• Biospec DMX Elixir has dextromethorphan in it. Before you start any new medicine, check the label to see if it has dextromethorphan in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Diabetes patients - Some brands of Biospec DMX Elixir may contain sugar. This may affect your blood sugar level. Read the label carefully before using Biospec DMX Elixir.


• Biospec DMX Elixir should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Biospec DMX Elixir while you are pregnant. It is not known if Biospec DMX Elixir is found in breast milk. Do not breast-feed while taking Biospec DMX Elixir.

Possible side effects of Biospec DMX Elixir:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Biospec DMX side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; excitement; hallucinations; slowed breathing.

Proper storage of Biospec DMX Elixir:

Store Biospec DMX Elixir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), away from heat, moisture, and light. Do not store in the bathroom. Keep Biospec DMX Elixir out of the reach of children and away from pets.

General information:

• If you have any questions about Biospec DMX Elixir, please talk with your doctor, pharmacist, or other health care provider.


• Biospec DMX Elixir is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Biospec DMX Elixir. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Biospec DMX resources

• Biospec DMX Side Effects (in more detail)
• Biospec DMX Use in Pregnancy & Breastfeeding
• Biospec DMX Drug Interactions
• 0 Reviews for Biospec DMX - Add your own review/rating

Compare Biospec DMX with other medications

• Cough
• Expectoration